胰岛素样生长因子-1 是一种多功能细胞增殖调控因子，生物学功能主要是刺激细胞有丝分裂，诱导及促进细胞分化。重组人胰岛素样生长因子-1(recombinant human insulin-like growth factor-1，rhIGF-1，1) 临床上主要用于治疗儿童原发性胰岛素样生长因子-1 严重缺乏导致的生长障碍和生长激素基因缺失且体内出现生长激素中和抗体患儿的生长不足，1还用于治疗胰岛素抵抗性糖尿病、神经损伤、骨质疏松、分解代谢等多种疾病。

参考资料：

1.Title:Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis.

Publication: Journal of Endocrinology (2009) 202, 287–297.

Application: support spermatogenesis in an androgen-independent manner (Leal et al. 2006)

2.Title:Suppression of Anoikis by SKP2 Amplification and Overexpression Promotes Metastasis of Esophageal Squamous Cell Carcinoma .

Publication:doi: 10.1158/1541-7786.MCR-08-0092 Mol Cancer Res January 2009 7; 12

3.Title:MECHANISMS OF BIOMATERIAL MEDIATED FIBROTIC RESPONSES AND STRATEGIES TO IMPROVE TISSUE REACTIONS TO BIOMATERIAL IMPLANTS.

Publication:THE UNIVERSITY OF TEXAS AT ARLINGTON

May 2010

4. Title: Cancer-Associated Carbonic Anhydrases IX and XII: Effect of Growth Factors on Gene Expression in Human Cancer Cell Lines.

Publication: Journal of Cancer Molecules 5(3): 73-78, 2010.